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CCD 1

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N-糖基化 1

三维形貌测量 1

严重急性呼吸系统综合征冠状病毒2 （SARS-CoV-2） 1

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前沿技术与中医药创新发展 1

动力学性质 1

动态状态估计器；卡尔曼滤波；测试误差；支路参数误差；负荷突变 1

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Deformable image registration with geometric changes

Yu LIU,Bo ZHU

《信息与电子工程前沿（英文）》 2015年第16卷第10期页码 829-837 doi: 10.1631/FITEE.1500045

摘要： Geometric changes present a number of difficulties in deformable image registration. In this paper, we propose aglobal deformation framework to model geometric changes whilst promoting a smooth transformation between source and target images. To achieve this, we have developed an innovative model which significantly reduces the side effects of geometric changes in image registration, and thus improves the registration accuracy. Our key contribution is the introduction of a sparsity-inducing norm, which is typically L1 norm regularization targeting regions where geometric changes occur. This preserves the smoothness of global transformation by eliminating local transformation under different conditions. Numerical solutions are discussed and analyzed to guarantee the stability and fast convergence of our algorithm. To demonstrate the effectiveness and utility of this method, we evaluate it on both synthetic data and real data from traumatic brain injury (TBI). We show that the transformation estimated from our model is able to reconstruct the target image with lower instances of error than a standard elastic registration model.

关键词： Geometric changes Image registration Sparsity Traumatic brain injury (TBI)

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Probabilistic analysis of secant piles with random geometric imperfections

《结构与土木工程前沿（英文）》 2021年第15卷第3期页码 682-695 doi: 10.1007/s11709-021-0703-2

摘要： The failure to achieve minimum design overlap between secant piles compromises the ability of a structure to perform as designed, resulting in water leakage or even ground collapse. To establish a more realistic simulation and provide guidelines for designing a safe and cost-effective secant-pile wall, a three-dimensional model of a secant pile, considering the geometric imperfections of the diameter and direction of the borehole, is introduced. An ultrasonic cross-hole test was performed during the construction of secant piles in a launching shaft in Beijing, China. Based on the test results, the statistical characteristics of the pile diameters and orientation parameters were obtained. By taking the pile diameter D, inclination angle β, and azimuth angle α as random variables, Monte Carlo simulations were performed to discuss the influence of different design parameters on the probability density functions of the overlap of secant piles. The obtained results show that the randomness of the inclination angle and pile diameter can be well described by a normal distribution, whereas the azimuth angle is more consistent with a uniform distribution. The integrity of the secant-pile wall can be overestimated without considering the uncertainty of geometric imperfections. The failure of the secant-pile wall increases substantially with increasing spatial variability in drilling inclination and diameter. A design flowchart for pile spacing under the target safety level is proposed to help engineers design a safe and economical pile wall.

关键词： secant piles ultrasonic cross-hole testing probabilistic analysis reliability-based design random imperfections

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Zinc modification of Ni-Ti as efficient NiZnTi catalysts with both geometric and electronic improvements

《化学科学与工程前沿（英文）》 2022年第16卷第4期页码 461-474 doi: 10.1007/s11705-021-2072-8

摘要： The catalytic hydrogenation of nitroaromatics is an environmentally friendly technology for aniline production, and it is crucial to develop noble-metal-free catalysts that can achieve chemoselective hydrogenation of nitroaromatics under mild reaction conditions. In this work, zinc-modified Ni-Ti catalysts (Ni_xZn_yTi₁) were fabricated and applied for the hydrogenation of nitroaromatics hydrogenation. It was found that the introduction of zinc effectively increases the surface Ni density, enhances the electronic effect, and improves the interaction between Ni and TiO₂, resulting in smaller Ni particle size, more oxygen vacancies, higher dispersion and greater concentration of Ni on the catalyst surface. Furthermore, the electron-rich Ni^δ^– obtained by electron transfer from Zn and Ti to Ni effectively adsorbs and dissociates hydrogen. The results reveal that Ni_xZn_yTi₁ (Ni_0.5Zn_0.5Ti₁) shows excellent catalytic performance under mild conditions (70 °C and 6 bar). These findings provide a rational strategy for the development of highly active non-noble-metal hydrogenation catalysts.

关键词： bimetal strategy oxygen vacancy non-noble metal catalyst hydrogenation aromatic nitro compounds

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Cellular changes in bronchoalveolar lavage fluid in hyperoxia-induced lung injury

HE Xinbiao, ZHAO Wei

《医学前沿（英文）》 2008年第2卷第4期页码 370-373 doi: 10.1007/s11684-008-0071-5

摘要： It is well known that high concentration oxygen exposure is a model of acute lung injury (ALI). However, controversy exists over the mechanism. This study was designed to clarify the cellular characteristics in bronchoalveolar lavage fluid (BALF) and body weight loss of rats exposed to oxygen(> 90%). Young male Wistar rats, aged 6 weeks, were divided into three groups: (1) room air group (exposed to room air, = 22); (2) hyperoxia < 48 h group (exposed to over 90% oxygen for less than 48 h, = 18); (3) hyperoxia 66–72 h group (exposed to over 90% oxygen for 66–72 h group, = 7). Compared to the room air group, the total cell counts in the hyperoxia 66–72 h group decreased, whereas the neutrophils increased significantly. The body weights of the rats exposed to room air continued to increase. However, the body weights of oxygen-exposed rats increased slightly on the first day and weight loss was seen from the second day. All rats were noted to have bilateral pleural effusion in the hyperoxia 66–72 h group. The data suggests that (1) an increase in neutrophil count is an evident feature of hyperoxia-induced lung injury; (2) high concentration oxygen exposure can give rise to anorexia and malnutrition, which may play a role in hyperoxia-induced lung injury. Blocking neutrophil influx into lung tissue in the early phase and improving malnutrition are two effective methods to reduce hyperoxic lung injury.

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环境一号卫星A/B星数据自动几何精校正设计研究

熊文成,申文明,王桥,史园莉,肖如林,付卓

《中国工程科学》 2014年第16卷第3期页码 37-42

摘要：

环境一号卫星A/B星是我国自主研制的小卫星星座，其在轨稳定运行近5年，并稳定获取了大量高质量的观测数据，实现对这些观测数据的几何精校正处理，对发挥环境星宏观、动态的生态环境监测有着重要意义。本文首先分析了环境一号卫星参数特点以及环境一号卫星2级数据（系统几何校正后的数据）的几何特点。基于此，设计了环境一号卫星各载荷总体几何精校正方法流程以及charge-coupleddevice（CCD）相机自动几何精校正方法。实际运行数据表明，该方法可以较好地实现环境一号卫星各载荷数据的自动几何精校正，环境一号卫星CCD相机自动几何精校正图像精度可达到2个像素以内，同星不同载荷图像之间自动匹配方法可以获取小于1个像素的图像匹配精度。

关键词：环境一号卫星自动几何精校正 CCD

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Elucidate long-term changes of ozone in Shanghai based on an integrated machine learning method

《环境科学与工程前沿（英文）》 2023年第17卷第11期 doi: 10.1007/s11783-023-1738-5

摘要：

● A novel integrated machine learning method to analyze O₃ changes is proposed.

关键词： Ozone Integrated method Machine learning

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Isogeometric analysis based on geometric reconstruction models

《机械工程前沿（英文）》 2021年第16卷第4期页码 782-797 doi: 10.1007/s11465-021-0648-0

摘要： In isogeometric analysis (IGA), the boundary representation of computer-aided design (CAD) and the tensor-product non-uniform rational B-spline structure make the analysis of three-dimensional (3D) problems with irregular geometries difficult. In this paper, an IGA method for complex models is presented by reconstructing analysis-suitable models. The CAD model is represented by boundary polygons or point cloud and is embedded into a regular background grid, and a model reconstruction method is proposed to obtain the level set function of the approximate model, which can be directly used in IGA. Three 3D examples are used to test the proposed method, and the results demonstrate that the proposed method can deal with complex engineering parts reconstructed by boundary polygons or point clouds.

关键词： isogeometric analysis reconstruction model level set function trimmed element point cloud

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Effects of critical geometric parameters on the optical performance of a conical cavity receiver

Hu XIAO, Yanping ZHANG, Cong YOU, Chongzhe ZOU, Quentin FALCOZ

《能源前沿（英文）》 2019年第13卷第4期页码 673-683 doi: 10.1007/s11708-019-0630-2

摘要： The optical performance of a receiver has a great influence on the efficiency and stability of a solar thermal power system. Most of the literature focuses on the optical performance of receivers with different geometric shapes, but less research is conducted on the effects of critical geometric parameters. In this paper, the commercial software TracePro was used to investigate the effects of some factors on a conical cavity receiver, such as the conical angle, the number of loops of the helical tube, and the distance between the focal point of the collector and the aperture. These factors affect the optical efficiency, the maximum heat flux density, and the light distribution in the conical cavity. The optical performance of the conical receiver was studied and analyzed using the Monte Carlo ray tracing method. To make a reliable simulation, the helical tube was attached to the inner wall of the cavity in the proposed model. The results showed that the amount of light rays reaching the helical tube increases with the increasing of the conical angle, while the optical efficiency decreases and the maximum heat flux density increases. The increase in the number of loops contributed to an increase in the optical efficiency and a uniform light distribution. The conical cavity receiver had an optimal optical performance when the focal point of the collector was near the aperture.

关键词： parabolic collector conical cavity receiver critical geometric parameters optical performance

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From gut changes to type 2 diabetes remission after gastric bypass surgeries

null

《医学前沿（英文）》 2013年第7卷第2期页码 191-200 doi: 10.1007/s11684-013-0258-2

摘要：

Increasing evidence suggests that the gut may influence the host’s metabolism and ultimately change the outcomes of type 2 diabetes mellitus (T2DM). We review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgery, and discuss the potential mechanisms underlying the above relationship: gut anatomical rearrangement, microbial composition changes, altered gut cells, and gut hormone modulation. However, the exact changes and their relative importance in the metabolic improvements after gastric bypass surgery remain to be further clarified. Elucidating the precise metabolic mechanisms of T2DM resolution after bypass surgery will help to reveal the molecular mechanisms of pathogenesis, and facilitate the development of novel diagnoses and preventative interventions for this common disease.

关键词： gastric bypass T2DM gut

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Mechanical and geometric advantages in compliant mechanism optimization

Michael Yu WANG

《机械工程前沿（英文）》 2009年第4卷第3期页码 229-241 doi: 10.1007/s11465-009-0066-1

摘要： This paper presents a focused examination of the mechanical and geometric advantages in compliant mechanisms and their ramifications in the design formulations of compliant mechanisms posed as a topology optimization problem. With a linear elastic structural analysis, we quantify mechanical (and geometric) advantage in terms of the stiffness elements of the mechanism's structure. We then analyze the common formulations of compliant mechanism optimization and the role of the external springs added in the formulations. It is shown that the common formulations using mechanical (or geometric) advantage would directly emulate at best a rigid-body linkage to the true optimum design. As a result, the topology optimization generates point flexures in the resulting optimal mechanisms. A case study is investigated to demonstrate the resulting trends in the current formulations.

关键词： compliant mechanisms topology optimization mechanical advantage pseudo rigid-body mechanisms

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Study on microbial protein and the mechanism of solid-state fermentation with periodical dynamic changes

FU Xiaoguo, CHEN Hongzhang, LI Hongqiang, MA Runyu

《化学科学与工程前沿（英文）》 2007年第1卷第2期页码 113-117 doi: 10.1007/s11705-007-0021-9

摘要： The effect of different extraction and purification conditions on the microbial protein obtained from solid-state fermentation (SSF) and the effect of periodical dynamic changes of air on protein have been studied. The mechanism of solid-state fermentation with periodical dynamic changes of air is also discussed. Compared with static solid-state fermentation, periodical dynamic changes of air afford a higher protein mass; from 1 g of the fermentation microbe, 5.3 mg of the intracellular protein (an increase of 34.63%) and 9.09 mg of the extracellular protein (an increase of 17.8%) were obtained on the sixth day of fermentation. The filter paper activity and carboxymethyl cellulose activity (FPA and CMCase) of the extracellular protein are 1.739 μmol/s and 109.592 μmol/s, respectively, which represent increases of 60.1% and 21.2% over the corresponding values for static solid-state fermentation. The FPA and CMCase of the intracellular protein are 0.245 μmol/s and 6.392 μmol/s, respectively, which represent decreases of 22.2% and 38.7% over the corresponding values for static solid-state fermentation. The enzyme activity of the microbial extracellular protein in solid-state fermentation with periodical dynamic changes of air on the fifth day is nearly equal to that on the sixth day without periodical dynamic changes of air, so the period of fermentation can be shortened. The sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) experiments suggest that pulsating air pressure stimulation leads to a decrease in the amount of protein component with molecule mass of about 80400Da, and an increase in the amount of protein component with molecule mass of about 28520Da.

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经济供电半径的Fuzzy几何规划模型与优选方法

曹炳元

《中国工程科学》 2001年第3卷第3期页码 52-55

摘要：

变电所供电半径的选择是一个复杂的问题。为了确定最佳供电半径，减少投资，降低损耗，建立了Fuzzy环境下的变电所供电半径选择的几何规划模型。它包括软约束问题和含Fuzzy系数的问题。通过数值实例的计算，验证所建立的模型，与静态和动态的优化数学模型如控制模型和经典几何规划模型相比较，包含更多的信息，且获得了更满意的结果。

关键词： Fuzzy几何规划经济供电半径优选变电所容(数)量

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Geometric optimization model for the solar cavity receiver with helical pipe at different solar radiation

Chongzhe ZOU, Huayi FENG, Yanping ZHANG, Quentin FALCOZ, Cheng ZHANG, Wei GAO

《能源前沿（英文）》 2019年第13卷第2期页码 284-295 doi: 10.1007/s11708-019-0613-3

摘要： In consideration of geometric parameters, several researches have already optimized the thermal efficiency of the cylindrical cavity receiver. However, most of the optimal results have been achieved at a fixed solar radiation. At different direct normal irradiance (DNI), any single optimal result may not be suitable enough for different regions over the world. This study constructed a 3-D numerical model of cylindrical cavity receiver with DNI variation. In the model of a cylindrical cavity receiver containing a helical pipe, the heat losses of the cavity and heat transfer of working medium were also taken into account. The simulation results show that for a particular DNI in the range of 400 W/m to 800 W/m , there exists a best design for achieving a highest thermal efficiency of the cavity receiver. Besides, for a receiver in constant geometric parameters, the total heat losses increases dramatically with the DNI increasing in that range, as well as the temperature of the working medium. The thermal efficiency presented a different variation tendency with the heat losses, which is 2.45% as a minimum decline. In summary, this paper proposed an optimization method in the form of a bunch of fitting curves which could be applied to receiver design in different DNI regions, with comparatively appropriate thermal performances.

关键词： cylindrical cavity receiver 3-D numerical simulation geometric optimization direct normal irradiation

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Innate immune responses in RNA viral infection

Qian Xu, Yuting Tang, Gang Huang

《医学前沿（英文）》 2021年第15卷第3期页码 333-346 doi: 10.1007/s11684-020-0776-7

摘要： RNA viruses cause a multitude of human diseases, including several pandemic events in the past century. Upon viral invasion, the innate immune system responds rapidly and plays a key role in activating the adaptive immune system. In the innate immune system, the interactions between pathogen-associated molecular patterns and host pattern recognition receptors activate multiple signaling pathways in immune cells and induce the production of pro-inflammatory cytokines and interferons to elicit antiviral responses. Macrophages, dendritic cells, and natural killer cells are the principal innate immune components that exert antiviral activities. In this review, the current understanding of innate immunity contributing to the restriction of RNA viral infections was briefly summarized. Besides the main role of immune cells in combating viral infection, the intercellular transfer of pathogen and host-derived materials and their epigenetic and metabolic interactions associated with innate immunity was discussed. This knowledge provides an enhanced understanding of the innate immune response to RNA viral infections in general and aids in the preparation for the existing and next emerging viral infections.

关键词： innate immune viral infection intercellular signaling metabolic changes epigenetic changes

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Application of consistent geometric decomposition theorem to dynamic finite element of 3D composite beam

Iman FATTAHI, Hamid Reza MIRDAMADI, Hamid ABDOLLAHI

《结构与土木工程前沿（英文）》 2020年第14卷第3期页码 675-689 doi: 10.1007/s11709-020-0625-4

摘要： Analyzing static and dynamic problems including composite structures has been of high significance in research efforts and industrial applications. In this article, equivalent single layer approach is utilized for dynamic finite element procedures of 3D composite beam as the building block of numerous composite structures. In this model, both displacement and strain fields are decomposed into cross-sectional and longitudinal components, called consistent geometric decomposition theorem. Then, the model is discretized using finite element procedures. Two local coordinate systems and a global one are defined to decouple mechanical degrees of freedom. Furthermore, from the viewpoint of consistent geometric decomposition theorem, the transformation and element mass matrices for those systems are introduced here for the first time. The same decomposition idea can be used for developing element stiffness matrix. Finally, comprehensive validations are conducted for the theory against experimental and numerical results in two case studies and for various conditions.

关键词： composite beam dynamic finite element degrees of freedom coupling experimental validation numerical validation